Research Projects
Ongoing and completed computational research projects. Each project page includes methods, findings, and associated publications.
Project Exodus
activeGeneralizable conservation mapping pipeline for RNA viruses
A five-phase bioinformatics pipeline analyzing sequence conservation and vaccine/drug target viability across RNA viruses: Rotavirus → Rhinovirus → SARS-CoV-2 → Influenza → HIV. Built on MAFFT multiple sequence alignment with custom conservation scoring. Phase I (Rotavirus) complete; rotavirus genotype P[6] identified as primary vaccine gap driver with VP5* as high-value conserved target.
Pandoravirus DNA Analysis
activeRepeat element and structural analysis of giant virus genomes
Systematic genomic analysis of Pandoravirus species — among the largest known viruses with genomes exceeding 2.5 Mb. Investigation of repeat element distribution, putative gene identification, and comparison with Mimivirus and other nucleo-cytoplasmic large DNA viruses (NCLDVs).
Virus Runtime Environment (VRE)
activeFactorized model of host-viral compatibility
A novel computational framework testing whether host-viral compatibility can be decomposed into reusable, biologically grounded components. Uses a two-level schema (L1 functional, L2 molecular) validated via Acanthamoeba/Mimivirus contrast and rotavirus-gut bridge. Phase 1 complete with schema implementation.
PolyRx Risk — DDI Scoring API
activeDrug-drug interaction risk scoring for insurers and PBMs
An actuarial DDI risk scoring API combining pharmacological interaction data with population-level claims data to produce insurer-grade risk scores. Designed for workers' compensation carriers, pharmacy benefit managers, and health insurers. Phase A assessment complete.